Over the course of the last 40 years, much of Tim Lowly's art has been largely devoted to representing his daughter Temma. She is medically categorized as "multiply and profoundly disabled" and as such, one who has little personal agency. Lowly's art depicts Temma as a profoundly meaningful human and as a representative of a significant population that is relatively unseen and unconsidered in our society. Inspired by European Renaissance and Baroque painting and drawing, Lowly creates highly skilled, realistic drawings and paintings depicting Temma as a loved, valued, dignified, and mystical subject.