The City of East Wenatchee was incorporated in 1935, with an original town site of fifty acres.

Today the City's incorporated boundaries have grown to 1,873 acres.

Native Americans were the earliest residents of the East Wenatchee area; the Richey Clovis Cache discovered in 1987 in a local orchard places humans in East Wenatchee 11,250 years ago.

At the turn of the 20th Century, irrigation projects, including the Columbia Basin Project east of the region, opened the door for farming the barren land.

Orchards become the area's leading industry. In 1907, the first bridge built across the Columbia River connecting East Wenatchee and Wenatchee supported vehicle traffic and an irrigation pipeline that carried water to the west side of the valley.