The Lake Andes National Wildlife Refuge (NWR) Complex is comprised of Lake Andes NWR, Karl E. Mundt NWR, and Lake Andes Wetland Management District (WMD). The Complex headquarters is located on the east shore of Lake Andes.

Wildlife habitat on the Complex is extremely important to conservation of waterfowl, bald eagles, and grassland birds. The Complex occupies the southern portion of the Prairie Pothole Region - also known as the "Duck Factory." Many ducks rely on this habitat to successfully raise their young. The area also hosts migrant waterfowl populations in the tens and hundreds of thousands during peak fall and spring migration periods. The Karl E. Mundt NWR provides important habitat for 100-300 bald eagles. The Refuge protects one of the most critical bald eagle winter roosts in the country. Waterfowl and other ground-nesting birds also benefit from wetlands and grasslands protected on the Lake Andes WMD.