The Lafayette-Yalobusha Technical Center at Oxford was opened in the fall of 1983. An additional 11 acres of land for expansion was purchased in 1999. A 31,000-square-foot expansion was opened in August 2002.

Students attending the Oxford campus have access to modern classrooms, labs, and a learning resources center.

Since the opening of the 2002 expansion, the library has increased its volumes for a total of more than 9,000. At Oxford students can use online public access catalogs, Internet, and MAGNOLIA databases. The library area also includes a computer lab and a group study room.

Some of the most modern science labs in the state can be found at Lafayette-Yalobusha Technical Center. Lab stations, which accommodate four students each, feature Internet access allowing students to view numerous dissection collections. Using software like Dynamic Human, students can use computer graphics to view the human heart at work. Actual dissections also take place in the new labs - giving students the best of both worlds.

The center also includes a Related Studies Lab and Cosmetology Labs.