On May 30, 1818, in the home of Dr. John Pearson, in Perryville, KY in Mercer County (which became Boyle County in 1842) the Perryville Baptist Church was organized. There were a total of 24 members, all of whom had letters from the Old Salt River Church. These members adopted a constitution that they entered into which began, "We believe the Old and New Testaments are the inspired word of God and the only rule of Faith and Practice."

As the church had no regular meeting place, the first business meeting was held on June 5, 1818 in the cottage of Dr. Pearson. From then until the early part of 1822, the church met in various places, including the Methodist Brothers Camp and then started having services in the Union Meeting House. The South District Association met with the Perryville Baptist Church for the first time in 1829.

In November 1871, the church organized a Sunday School, with teachers in the following departments: Bible Class, Intermediate Girls, Intermediate Boys, and Primary Children. In April, 1873, the church resolved to build a meeting house. A building committee was appointed and the building project began. After the money was expended, the church had to borrow $500 to put a roof on the building. The church was dedicated in the fall of 1877. In 1880, the church voted to purchase 24 song books and an organ.

In 1915, the church voted to build Sunday School rooms. In 1916, the church voted to have the church wired for electric lights and the Sunday School Rooms were dedicated in August. In 1956, a 3-floor brick educational unit added to the sanctuary, at a cost of &60,000. In 1958, a new parsonage, valued at $20,000 was built and dedicated.

In 1963, the sanctuary was remodeled, including a new baptistry and choir loft. In 1965 the church purchased the Dr. Hopper property for $12,000, which was used as Sunday School rooms and is the current site of the educational annex.

In 1970's the church voted to air condition, add pews, and add a sound system in the sanctuary.

In 1980's at a cost of $133,000, the church voted to build the educational annex. Also, the church purchased the Watts property, which is currently used for parking, for $45,000 and purchased the first church van. That was also the first year of the Christmas Eve Silent Lord's Supper that has been an annual event since that time.

In the 1990's, the church has increased emphasis on missions. The church voted to purchase the baby grand piano and a church bus. A scholarship program was established and a new sound system installed in the sanctuary. The church celebrated its 175th anniversary.

In the 2000's, the church has voted to build additional educational space. It will be a 2-story, brick building at a cost in excess of $650,000.

Perryville Baptist Church has a long, interesting history. She has always tried to be loyal to the word of God and keep the zeal of early members to proclaim the gospel to the world in which men, women, and children live.