The organization of the Pioneer Regional School Corporation was brought about by the Reorganization Act of Indiana of 1959. This act required that all schools within the state of Indiana be organized into single unit school corporations of at least one thousand students in attendance. Pioneer Regional School Corporation is one of the few regional corporations in the state. Schools are known as "regional corporations" because they encompass a geographical area that is located in more than one county.

The Pioneer Regional School Corporation consists of five townships, four of which are in Cass County-Boone, Harrison, Jefferson, and Noble-and one in White County-Cass township. The corporation has in it 153 square miles and includes the communities of Lucerne, Headlee, Lake Cicott, and Royal Center. The only existing and occupied building eliminated during the reorganization process was the school at Lucerne, which was closed in 1966 when the Jr.-Sr. High School building was completed and occupied. The corporation also has one elementary building, which, along with the Jr.-Sr. High School, is located in Royal Center.