Acts who have appeared on the 12th & Porter stage over the years include: Neil Young, Vince Gill, Kings of Leon, Run-DMC, Townes Van Zandt, and John Prine.

Since its creation, 12th & Porter has been a quintessential space in the Nashville music scene. Because of the eclectic mix of artists it attracted and its prime location in the heart of Nashville, 12th & Porter quickly became one of the Southeast's most distinguished concert venues. For over 25 years, fans and artists have gathered on a nightly basis to experience live music in an environment that truly appreciates the music that is being created on stage.

Following its transfer of ownership in February 2015, 12th & Porter underwent extensive structural renovations to further improve the sound, production, and overall concert experience for fans and artists. The recently renovated room has a sleek interior that was specifically engineered to produce excellent sound for its listeners, regardless of where they are standing in the venue.