Organized in 1841 with thirty charter members by the Rev. Isaac S. Bonham, the Greeneville CP Church has pointed its spire heavenward since 1860 from its present location on North Main and Church Streets. Here Pastor John P. Holtsinger began construction of the first unit of the present building on a lot purchased from Senator (afterwards, President) Andrew Johnson for $1200. This spot has been the scene of a Cumberland Presbyterian Newspaper, The American Presbyterian, edited by the Rev. Joseph B. Dobson in the 1850’s.

Pastor Holtsinger was not destined to see the building completed until after the War Between the States, in which he served as a chaplain. The church also saw military duty serving as a stable and hospital, and was “wounded” with the cannon ball in the front wall on September 4, 1864. On that same day Gen. John H. Morgan was killed in the Williams garden across the street. Col. John H. Doughty completed the building in 1875, and the exterior woodwork of the cornice and steeple were designed and executed by James F. Fields and Robert D. Maloney. Done in the style of the Greek Revival, the church is on the National Register of Historic Places. The spire is surmounted by a figure of the Angel Gabriel in gold leaf.

In the late 1980’s, the church again saw the need for expanded facilities. A building and lot west of the sanctuary on Church Street was purchased and incorporated into the present structure, providing space for large gatherings and Sunday School classes. The church continues to offer its space to outside groups as a part of its mission to the community.

Across the years, this church has extended its love and concern to all those seeking a warm Christian fellowship. There are now over 350 active members and they come from more than twenty denominational backgrounds. While giving full support to the program of the denomination, this church is yet ecumenical in the best sense of the term. It welcomes to its worship and membership those of all persuasions who acknowledge Jesus Christ as Lord, and it works in harmony with all other Christians of the community to the glory of God and for the service of humankind.