St. Mary's High School is a co-educational, Catholic, college prepartory school located in Lancaster, New York, 4.5 miles SE of the Buffalo Niagara International Airport and 14.5 East of downtown Buffalo. A faith community within the Diocese of Buffalo, St. Mary's takes pride in educating the whole student, as reflected in our motto above. St. Mary's enrollment includes students in grades 9-12 from four counties and approximately 30 school districts.

St. Mary's High School offers a challenging curriculum featuring a variety of Honors and Advanced Placement courses. In the spirit of educating the whole student there are many extracurricular activities including a very successful Athletic program, a high-quality Performing Arts department and a whole list of clubs and organizations catering our students interests.